Plaquenil is an anti-rheumatic, anti-malarial, antiparasitic, and immuno-modulatory medication. In the 1950s, it was approved by the FDA to prevent and treat malaria. Later, it was also approved to treat lupus and rheumatoid arthritis. Plaquenil tablets lower your immune system’s ability to cause inflammation. It is recommended as a disease-modifier, in other words, to decrease pain and swelling, and prevent joint damage and disability.
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Plaquenil contains the active ingredient hydroxychloroquine, which is available as a generic medication. A generic drug is an exact copy of the active drug in a brand-name medication. It is considered to be as safe and effective as the original drug. Generics tend to cost less than brand-name drugs. Probably the most interesting thing about medication is that it comes with a pretty significant safety profile. Both generic and brand-name come as 200-mg and 400-mg tablets. Only we have Hydroxychloroquine in Australia at affordable prices for you!
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Fast Facts about Hydroxychloroquine
Common brand: Plaquenil
Drug Form: Tablet (film-coated)
Dosage: 200 mg, 400 mg
Generic status: Lower-cost generic available
Drug class: Antimalarial quinolines, Antirheumatics
Price: around $56 for 10 generic tablets 200 mg.
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What is Hydroxychloroquine used for?
Plaquenil (Hydroxychloroquine sulfate) is a drug used to treat autoimmune diseases. This type of disease happens when the body’s immune system attacks its healthy tissue.
The drug, originally approved for malaria in 1955, has been approved for decades as a disease-modifying antirheumatic drug to treat rheumatoid arthritis (RA) and systemic lupus erythematosus and is used in the treatment of juvenile idiopathic arthritis, Sjögren’s syndrome, which causes dry eyes and dry mouth.
For RA and lupus, Plaquenil Hydroxychloroquine is recommended as a disease-modifier, meaning that it:
- Decreases pain
- Lessens inflammation
- Prevents joint damage
- Helps retain physical ability.
In addition to its benefits, Plaquenil has been found to: improve lipid profiles; control glucose and reduce the risk of diabetes mellitus; lower the risk of thrombosis in certain at-risk people; treat porphyria cutanea tarda, which is a rare blood disorder. While Plaquenil is not yet an FDA-approved treatment option for the novel coronavirus, some physicians have begun to recommend the medication. You can’t go wrong if you choose to buy Hydroxychloroquine online in Australia.
Plaquenil for potential COVID-19 Treatment
A coronavirus identified in 2019, SARS-CoV-2, has caused a pandemic of respiratory illness, called COVID-19. Some people infected with the coronavirus have mild COVID-19 illness, and others have no symptoms at all. In some cases, however, this disease can lead to respiratory failure, lasting lung, and heart muscle damage, nervous system problems, kidney failure or death. When the pandemic first began, Plaquenil and Ivermectin in Australia were considered as possible treatment options. Researchers are actively studying the safety and efficacy of medication in treating disease.
A research group in France released the results of a study involving 20 coronavirus patients treated with Plaquenil (600 mg daily). After 6 days of treatment, 70% of the Hydroxychloroquine patients tested negative for the virus, compared to 12.5% of the control group. Initially, the Food and Drug Administration (FDA) allowed these pills to be used for medical emergencies due to COVID-19. And doctors in many hospitals started using hydroxychloroquine routinely in COVID-19 patients. But even at the time of its issuing, the FDA noted that a person should only use the drug when a healthcare professional feels the possible benefits outweigh the risks.
Plaquenil for Lupus
With lupus, which is an autoimmune disease, your immune system attacks your own body. This leads to pain and swelling in your body. In particular, lupus can affect your skin, joints, and organs such as your kidneys and heart. It’s not known for sure what causes lupus. However, the condition may be related to your genetics, hormones, or environment.
Research into the wide-ranging effects of Plaquenil Hydroxychloroquine has revealed many important benefits in the treatment of lupus. Benefits include a decrease in the number of disease flares; the ability to delay the absorption of ultraviolet light; a decrease in damage from the disease over time. Given the drug’s many and varied beneficial effects and its excellent long-standing safety profile, most rheumatologists believe that Plaquenil medication should be taken by people with lupus throughout their lifetime.
Plaquenil for rheumatoid Arthritis
Rheumatoid arthritis (RA) is an autoimmune disease in which the body’s immune system attacks its own tissue. It is a chronic disorder that increases in prevalence with advancing age, but it can begin at any age. Excess immune cells and immune proteins chronically flood the joints and other tissue, attacking these structures as they would combat an infectious organism.
Hydroxychloroquine can be a great choice to reduce rheumatoid arthritis symptoms when taken correctly. About 65% of people treated with hydroxychloroquine experience improvement in their condition. Plaquenil for rheumatoid arthritis does not work straight away. It may take 8 to 12 weeks for symptoms to start to improve. The full effect of treatment may take up to 26 weeks. The medication is generally well-tolerated and has even been found safe overall for women who are pregnant or breastfeeding.
Mechanism of action
Hydroxychloroquine has been traditionally used as an antimalarial drug in areas of the world where tolerance to the drug has not developed. Though the exact mechanism of action against malaria is unclear, it is known that the drug accumulates in the malaria parasite lysosomes, which raises the pH and interferes with the parasite’s ability to break down hemoglobin. This, in turn, prevents normal growth and replication of the parasite.
Hydroxychloroquine is also considered a DMARD and is used to treat rheumatic diseases such as rheumatoid arthritis and systemic lupus erythematosus. In inflammatory conditions, it works by blocking toll-like receptors on plasmacytoid dendritic cells (PDCs). Hydroxychloroquine reduces activation of dendritic cells and inflammation by decreasing TLR signaling. The Toll-like receptor 9 (TLR 9) recognizes DNA-containing immune complexes and leads to the production of interferon and causes the dendritic cells to mature and present antigen to T cells, therefore reducing the anti-DNA auto-inflammatory process.
How should this medicine be used?
This medication comes as tablets that are taken by mouth. It’s available in strength: 200 mg and 400 mg. The Plaquenil dosage will depend on several factors. These include:
- the type and severity of the condition for which you’re using the medicine
- your age
- your body weight
- other medical conditions you may have
- side effects from pills.
Take it on a regular schedule, meaning at the same time each day. If you miss a dose, take it as soon as you remember. If it is very near the time of the next dose, skip the missed dose and continue with your normal dosing schedule. Taking Hydroxychloroquine with food and/or milk can help prevent stomach upset.
What is the dosage for Plaquenil Hydroxychloroquine?
The usual adult dose for treating malaria is 800 mg initially, followed by 400 mg 6-8 hours later and then 400 mg at 24 hours and 48 hours. The dose for malaria prevention is 400 mg every week starting 1 or 2 weeks before exposure and for 4 weeks after leaving the high-risk area.
The recommended adult dose for rheumatoid arthritis is 400-600 mg daily for 4-12 weeks followed by 200-400 mg daily.
Systemic lupus erythematosus is treated with 400 mg once or twice daily for several weeks then 200-400 mg daily. Hydroxychloroquine should be taken with food to reduce stomach upset.
How long is treatment continued?
The medication may take some time to begin working in your body. And how quickly it works will depend on the reason why you’re taking the drug. Taking the medication for the full six months can help you decide between continuing it.
If you stop hydroxychloroquine treatment for more than a few weeks there is a risk that your condition may worsen.
Where to buy Hydroxychloroquine in Australia?
Purchasing medicines online is a hassle-free way to get them delivered to your door. Often, you might have to wait in line at the physical store to get your medicines. It may happen that when you reach the store, they might have run out of your desired medicine. Therefore, online pharmacies eliminate all this hassle and provide you a simple mechanism to buy medicines online. The online pharmacy will tell if the Plaquenil is in stock or not and save you the hassle of visiting the store.
Here are the major benefits of our online pharmacy:
- Hydroxychloroquine over-the-counter.
- Flexible Delivery.
- Reduced Cost.
Apart from safety, online pharmacies ensure convenience and reduce the risk of getting COVID. We offer fast shipping so you get what you want, when you need it because your health is important to us.
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How much does Plaquenil cost in Australia?
Medicine prices at an online pharmacy are lower than that of a physical pharmacy. This is primarily because there is no cost of maintaining the premise. Apart from that, there are no operational costs for the online pharmacy. It leads to a reduction in the prices of medicine. Also, online pharmacies can acquire Plaquenil generic at a cheaper cost than their counterparts. Our pharmacy can save you both time and money.
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What should I discuss with my healthcare provider before taking Plaquenil?
- Be sure to notify your other physicians that you are taking this drug. Every person starting this medication should have a baseline ophthalmologic exam within the first year, and regular screenings thereafter.
- Tell your doctor if you have any of these conditions: psoriasis, porphyria, liver disease, alcoholism, or glucose-6-phosphate dehydrogenase (G-6-D) deficiency.
- Do not smoke while taking antimalarial medications, since smoking actually reduces the benefits of these drugs. In fact, people with lupus should not smoke at all due to their increased risk of cardiovascular disease.
In most cases, you don’t need to be worried about drug interactions when taking hydroxychloroquine. List of hydroxychloroquine drug interactions: aminoglycoside antibiotics; medications for diabetes including insulin; medications for seizures; other antimalarials such as mefloquine, moxifloxacin; neostigmine; praziquantel (Biltricide); pyridostigmine; Rabies vaccine; agalsidase; cyclosporine; cimetidine; digoxin.
Do not take hydroxychloroquine if you:
- are allergic to hydroxychloroquine or any of its ingredients
- pre-existing retinopathy of the eye
- use in children below 6 years of age (200 mg tablets not adapted for weight < 35kg).
Hydroxychloroquine and alcohol
Avoid alcoholic beverages because they may increase your risk of liver problems while you are taking this drug.
Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely.
Use in pregnancy and breastfeeding
Hydroxychloroquine can be used in pregnancy if the mother’s condition is serious however you should ask your doctor about the benefits and risks of taking hydroxychloroquine while you are pregnant.
Plaquenil Hydroxychloroquine is generally well tolerated. The most common side effect is an upset stomach. This can often can be combatted by taking tablets with food or milk. A skin rash can occur in patients who are allergic to the medication.
Sometimes dizziness, blurred vision, or headache may occur. When the drug is taken over a long period of time, bleaching of the hair or gray discoloration of the skin can occur. Blood problems are very uncommon with this medication, so medication requires very little monitoring of blood tests.